Abstract: [Objective] The purpose of the present study is to investigate the antimicrobial type of florfenicol against the main primary causative bacteria of pig pneumonia.[Method]The minimum inhibitory concentration(MIC),minimal bactericidal concentration(MBC)and post-antibiotic effect(PAE)of florfenicol against Streptococcus suis,Pasteurella multocida and Actinobacillus pleuropneumoniae were determined.[Result]The MIC and MBC of florfenicol against the above pathogenic bacterias were 0.25～0.5 μg/mL and 2～4 μg/mL,respectively.The results have shown that the PAE increased with the increasing of drug concentration and extension of expose time,and time-kill curve also demonstrated that the antibacterial ability increased with the increasing of florfenicol concentration.[Conclusion]According to the results of PAE and time-kill curve in this study,we concluded that the florfenicol is typically concentration dependent against the main primary causative bacteria.

摘要： [目的]研究氟苯尼考对常见猪呼吸道病原菌的抗菌类型.[方法]对猪链球菌、猪胸膜肺炎杆菌及多杀性巴氏杆菌标准株进行最低抑菌浓度(MIC)、最小杀菌浓度(MBC)、抗菌后效应(PAE)的测定和体外杀菌曲线的绘制.[结果]氟苯尼考对上述病原菌的MIC和MBC依次为0.25～0.5 μg/mL和2～4 μg/mL,PAE结果显示,氟苯尼考对3株病原菌均随暴露浓度的增大和时间的延长其抗菌后效应明显延长;体外杀菌曲线表明,氟苯尼考对上述三株病原菌均有很好的抗菌能力,且抗菌效应随药物浓度的增大而明显增强.[结论]氟苯尼考对常见猪呼吸道病原菌的抗菌类型为浓度依赖型.