Abstract: 【 Objective 】 To increase the degradation rate of maize straw by employing response surface method based on Box-Behnken (BBK).【 Method 】Four salt tolerant strains (WH2,WH4,WH7 and WH9) with good ability of degrading cellulose were isolated from saline alkali soil of corn straw manure. Based on morphologic observation,physiological and biochemical characteristics and molecular identification,they were identified as Bacillus cereus, Pseudomonas formosensis strain,Bacillus subtilis and Pseudomonas songnenensis respectively. On the basis of single-factor test analysis,Box-Behnken central composite design and response surface method (RSM),while taking the degradation rate of maize straw as the response value,response surface method was applied to analyze the influence of various factors and their interaction on the degradation rate of maize straws,thus optimizing the progress ratio of bacteria.【 Result 】The result showed that the optimum conditions were as follows:When the straw is 2.0 g,the inoculation quantity of the four strains (WH2,WH4,WH7,WH9) is 0.31 g, 0.21 g, 0.32 g and 0.22 g,respectively,and the rate of straw degradation reached the maximum.【 Conclusion 】Under these optimal conditions,the predictive value of the degradation rate of straw is 61.17%,meanwhile the verification value is 60.90%. There is only 0.27% difference between predictive and verification value,which has proved the rationality and effectiveness of RSM. The experiment has provided a theoretical basis for the microbial degradation of corn straws in Xinjiang.