Abstract: 【Objective】 The study aims to provide a basis for guiding the rational use of insecticides and resistance management for efficient controlling Ostriniafurnacalis through resistance monitoring and detection of field populations to the commonly used insecticides mainly including diamides, acting on the ryanodine receptor (RyR). 【Methods】 In this study, it was monitored for the resistance to insecticides including chlorantraniliprole, cyantraniliprole, aricaandlangat against O.furnacalis from Urumqi (UQ), Shule (SL1,), Yining (YN1) and Zepu (ZP) in 2018 and Urumqi (UQ), Shule(SL2), Yining (YN2) and Changji (CJ) in 2019 in Xinjiang using artificial diet dipping method. Meanwhile, we analyzed and detected expression changes and mutation of ryanodine receptor genes in the populations collected in 2018 and 2019 by quantitative real-time PCR (qPCR) and PCR amplification, respectively. 【Results】 SL1 population had reduced sensitivity to chlorantraniliprole and medium level of resistance to arica with resistance ratios (RR) of 3.67 and 20.17-fold compared to a relatively sensitive population, respectively, YN1 population developed moderate resistance to cyantraniliprole and arica with RR being 15.26 and 14.10-fold respectively, and ZP population had a moderate level of resistance to arica and langat with RR of 10.97 and 13.48-fold, respectively. Among populations collected in 2019, SL2 population showed reduced sensitivity and the rest populations, namely UQ, YN2 and CJ, exhibited low to extremely high level resistance to cyantraniliprole with RR of 3.61, 8.14, 96.49 and 1,429-fold compared with the susceptible population JZ-S, respectively. The qPCR results showed that there was no significant difference in the expression of ryanodine receptor genes among the different field populations collected in 2018, while those in CJ and YN2 populations collected in 2019 increased significantly by 4.04 and 3.86 times compared with the susceptible strain. The gene mutation test results showed that it was detected for a mutation in the ryanodine receptor of CJ population, in which glutamic acid (E) was replaced by aspartic acid (D) at position 1,424 (E1424D) with 30% of the mutation frequency. 【Conclusion】 The resistance of the inter-field population of O. furnacalis in Xinjiang to diamides varies from low to medium levels, and its resistance was related to the increase of the expression and mutation of the ryanodine receptor gene.