Abstract: 【Objective】 To clarify the occurrence of weed varieties and select the appropriate combination of herbicide for the cotton area of southern Hebei Province. 【Methods】 The species and quantity of weeds in cotton fields were investigated by sampling them in a “W” pattern in Quzhou, Qiuxian, Cheng’an of Handan City and in Guangzong of Xingtai City. Then, the field plot experiment was conducted to determine the control effect and safety of the combination of 6 soil treatment agents on weeds in the local cotton field under the conditions of the recommended doses. 【Results】 The proportions of broad-leaved weeds, grass weeds and sedge weeds were 69.57%, 26.09% and 4.35%, respectively in the cotton area of southern Hebei Province. And annual weeds accounted for 78.26%, and perennial weeds accounted for 21.74%. Among them, there were 5 kinds of dominant weeds, including Chenopodium album L., Amaranthus retroflexus L., Portulaca oleracea L., Acalypha australis L., Eclipta prostrata L., and 11 kinds of common weeds. According to the weed species, the suitable combination of soil treatment agent was selected. The results showed that the plant control effect of pendimethalin, prometryne and oxyfluorfen combination with the dose of (990+1,125+216) g a.i./hm² on all the tested weeds was more than 90.82%, which was higher than other combinations, but the difference was not significant. The control effect on fresh weight of broadleaf weeds such as Chenopodium album L., Amaranthus retroflexus L. and Acalypha australis L. were 95.64%, 95.56% and 98.02%while the control effect on fresh weight of Digitaria sanguinalis (L.) Scop. was 85.99%. In summary, the control effect of this combination on the average fresh weight of the four tested weeds was 93.80%. 【Conclusion】 There were 23 species of weeds of 12 families in cotton fields in the south of Hebei Province, and there were mainly mixed with broadleaf weeds and grass weeds. Then according to the local weed kinds, a combination of pendimethalin, prometryne and oxyfluorfen with the dose of (990+1,125+216) g a.i./hm² was selected and it had the best effect on the control of local weeds.