Abstract: 【Objective】 To screen high-quality varieties of muskmelon grafted with thorny melon rootstocks combinations with excellent resistance to southern root knot nematode disease through artificial inoculation and identification of agronomic traits in the field and analyze the resistance of thorny melon rootstocks and the impact of grafting on the quality of muskmelonin the hope of promoting the development of pollution-free and high resistance muskmelon industry. 【Methods】 Using ZM1 and PI029 as rootstocks, the sweet melon varieties Huangmeng Crisp and Nasmi were grafted respectively,the yield and quality characteristics of different grafting combinations under facility pot cultivation conditions were analyzed, and high-quality grafting combinations suitable for production selected. 【Results】 There were significant differences in the quality of muskmelon between different germplasm resources and grafting of muskmelon. After grafting ZM1 and Nasmi, the soluble solids and fruit type index of muskmelon reached the highest, and the overall quality was desirable. However, there also remained shortcomings such as thicker skin and thinner flesh. ZM1 and Nasmi had the highest single melon weight and yield, which was beneficial for production and utilization. After the infection of southern root knot nematode, the activities of polyphenol oxidase (PPO), phenylalanine ammonia lyase (PAL), and tyrosine ammonia lyase (TAL) in the roots of Cucurbita pepo were significantly increased. 【Conclusion】 The grafting quality of ZM1 and Nasmi is the best, the single fruit weight is the highest, so its grafting combination is conducive to the promotion in the production.