Abstract: 【Objective】 To study the effects of reducing fertilizer application and increasing organic earthworm manure application on continuous cultivation of muskmelon in the hope of providing basic data for fertilization reduction and efficiency improvement in muskmelon production. 【Methods】 A new melon variety Huangmengcui was used as the material to study the effects of reducing chemical fertilizer and increasing organic vermicompost fertilizer on physiology, photosynthesis, yield, quality and root-tie nematode of continuous cropping melon. 【Results】 Compared with conventional fertilization, the vine length, fresh vine weight, dry vine weight, fresh root weight and dry root weight of T₂ treatment were increased by 26.3%, 39.9%, 23.5%, 80.6% and 53.3%, respectively. The net photosynthetic rate, stomatal conductance and transpiration rate treated with T₂ were increased by 38.6%, 45.4% and 66.1% compared with the control, respectively, and the differences were significant. The comprehensive analysis of yield index and quality index showed that the key quality index of melon reached the maximum under T₂ treatment, which was significantly different from the control. 【Conclusion】 T₂(Earthworm organic fertilizer 300 kg/667m²+compound fertilizer 50 kg/667m²) treatment has the best comprehensive performance, which can be used as a reference for continuous cultivation of melon fertilization.