Abstract: 【Objective】 To analyze the yield, agronomic traits, and grain quality of different grain sorghum varieties, select high-quality brewing sorghum varieties suitable for planting in the Hotan area of southern Xinjiang in the hope of providing raw material support for the development of the sorghum industry in this region. 【Methods】 25 grain sorghum varieties were used as materials to study the quality and agronomic traits. 【Results】 The results showed that there were differences in agronomic traits, yield, and brewing quality among different varieties. All 25 varieties grew and matured normally in the local area, with strong adaptability. Among them, there was only one extremely early maturing and dwarf variety, Longza 20 (95 d), and 20 medium stem varieties suitable for mechanized cultivation included Jinnuo 103, Jinza 111, and Jiliang 3. The yield variation ranged between 156.53 kg/667m² and 1182.61 kg/667m², with variety 2878A×IR60, the yield was the lowest, and the yield of Jiliang 4 was the highest. Longza 20 had the highest sugar content (18.42 g/kg) and lysine content (3.26 g/kg), but the lowest tannin content (0.66 g/kg). The starch content of Jiliang 3 and Jiliang 4 was the highest and the difference was not significant. 【Conclusion】 In summary, considering the characteristics of growth period, agronomic traits, yield, and quality, Jiliang 4 has better comprehensive performance with good promotion prospects, so it is recommended to prioritize planting in the Hotan area.